Mynd:Protease mechanisms.png
Stødd av hesi forskoðan: 800 × 307 pixels. Aðrar upploysnir: 320 × 123 pixels | 640 × 245 pixels | 1.437 × 551 pixels.
Upprunafíla (1.437 × 551 pixel, stødd fílu: 67 KB, MIME-slag: image/png)
Samandráttur
| Frágreiðing |
English: Differences in cysteine and serine proteolysis mechanisms.
The protease (black) performs a nucleophilic attack on peptide substrate (red) to form a tetrahedral intermediate. This breaks down by ejection of the first product, the substrate C-terminus, to form the acyl-enzyme intermediate. Water replaces the first product and hydrolysis occurs via a second tetrahedral intermediate to regenerate free enzyme. Indicated differences are (a) the deprotonated cysteine, (b) aspartate (grey) not present in all cysteine proteases, (c) concerted deprotonation of serine, (d) aspartate hydrogen bonding, (e) amide protonation of the first leaving group, (f) alcohol protonation of the serine leaving group. |
| Dagur | |
| Kelda | Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge. |
| Høvundur | Thomas Shafee |
Lisensur
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution 4.0 International license.
- Tú ert vælkomin til:
- at deila – at avrita, breiða út og senda verkið
- at remiksa – at tillaga ella broyta verkið
- Undir hesum treytum:
- ognan – Tú mást ognarskrivað verkið á ein slíkan hátt sum er útgreinaður av høvundanum ella lisenseigaranum (men ikki á nakran hátt ið kundi bent á at hesin hevur góðkent teg ella tína nýtslu av verkinum).
Søgan hjá fíluni
Trýst á dato/tíð fyri at síggja fíluna, sum hon sá út tá.
| Dagur/Tíð | Lítil mynd | Dimensjónir | Brúkari | Viðmerking | |
|---|---|---|---|---|---|
| streymur | 11. okt 2013 kl. 20:56 | | 1.437 × 551 (67 KB) | Evolution and evolvability | User created page with UploadWizard |
Myndarslóðir
Ongar síður slóða til hesa myndina.
Alheims fílunýtsla
Aðrar wkiir brúka hesa fílu:
- Nýtsla á es.wikipedia.org
- Nýtsla á zh.wikipedia.org
