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English: Performing multiple rounds of directed evolution is useful not only because a new library of mutants is created in each round but also because each new library uses better mutants as templates. The experiment is analogous to climbing a hill on a 'fitness landscape' where elevation represents the desired property. The goal is to reach the summit, which represents the best achievable mutant. Each round of selection samples mutants on all sides of the starting template (1) and selects the mutant with the highest elevation, thereby climbing the hill. This is repeated until a local summit is reached (2).
Dagur
Kelda Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge.
Høvundur Thomas Shafee

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I, the copyright holder of this work, hereby publish it under the following license:
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This file is licensed under the Creative Commons Attribution 4.0 International license.
Tú ert vælkomin til:
  • at deila – at avrita, breiða út og senda verkið
  • at remiksa – at tillaga ella broyta verkið
Undir hesum treytum:
  • ognan – Tú mást ognarskrivað verkið á ein slíkan hátt sum er útgreinaður av høvundanum ella lisenseigaranum (men ikki á nakran hátt ið kundi bent á at hesin hevur góðkent teg ella tína nýtslu av verkinum).

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